BMEN6396 - CRISPR and Genome Editing

BMEN 6396 CRISPR and Genome Editing (3 semester credit hours) The field of genome editing is experiencing a renaissance driven primarily by the repurposing of an immune response system utilized by bacteria and archaea. This system is characterized by the presence of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) stored in host genomes as memories of phage bacteria interactions. The use of the CRISPR-Cas9 system in higher organisms (including mammalian cells and animal models) has spurred myriads of applications critically relevant to agriculture, biomanufacturing, and human health. This course will introduce the general principles of CRISPR biology, provide training in the use of CRISPR for genome editing, highlight the latest research results, and discuss key scientific and technological challenges. (3-0) Y